EVALUATION OF THE SAFETY AND REACTOGENICITY OF THE VACCINE STRAIN “G20-LKV” OF THE GOAT POX VIRUS USED FOR SPECIFIC PREVENTION AGAINST NODULAR DERMATITIS OF CATTLE
Abstract
The article presents the results of studying the safety and reactogenicity of a heterologous vaccine of the goat pox virus, from the strain “G20-LKV” against nodular dermatitis of cattle. The safety and reactogenicity of the vaccine were tested on cattle and laboratory animals (white mice and rabbits). The results of the studies showed that subcutaneous administration of the vaccine to cattle, intramuscular to rabbits and intraperitoneal to white mice does not cause reactogenicity and adverse events in the body of the tested animals. Based on the analysis of the results obtained, it was found that the heterologous goat pox vaccine is harmless and areactogenic for cattle, rabbits and white mice.
About the Authors
A. K. Usembai
RSE “Scientific Research Institute of Biological Safety Problems”
Kazakhstan
Kazakhstan
Zh. B. Kondibaeva
RSE “Scientific Research Institute of Biological Safety Problems”
Kazakhstan
Kazakhstan
E. A. Shayakhmetov
RSE “Scientific Research Institute of Biological Safety Problems”
Kazakhstan
Kazakhstan
Zh. T. Amanova
RSE “Scientific Research Institute of Biological Safety Problems”
Kazakhstan
Kazakhstan
Zh. Zh. Sametova
RSE “Scientific Research Institute of Biological Safety Problems”
Kazakhstan
Kazakhstan
E. A. Bulatov
RSE “Scientific Research Institute of Biological Safety Problems”
Kazakhstan
Kazakhstan
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Review
For citations:
Usembai A.K., Kondibaeva Zh.B., Shayakhmetov E.A., Amanova Zh.T., Sametova Zh.Zh., Bulatov E.A. EVALUATION OF THE SAFETY AND REACTOGENICITY OF THE VACCINE STRAIN “G20-LKV” OF THE GOAT POX VIRUS USED FOR SPECIFIC PREVENTION AGAINST NODULAR DERMATITIS OF CATTLE. Biosafety and Biotechnology. 2021;(8):13-19. (In Russ.)
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