PRODUCTION SERIES OF INACTIVATED AVIAN INFLUENZA VACCINE MADE OF RECOMBINANT STRAIN RG43A (H5N8) SAFETY AND IMMUNOGENICITY TESTING

The paper presents the results of determining the safety and immunogenicity of the production series of the avian influenza inactivated vaccine made of the new recombinant strain A/gyrfalcon/Washington/41088-6/2014 (H5N8)-PR8-IDCDC-RG43A, hereinafter abbreviated RG43A (H5N8), prepared according to previously developed technology. The vaccine is safe with intramuscular administration of a five-fold dose of 2,5 cm3 for chickens of 88 days age. The vaccine is immunogenic when administered intramuscularly at a dose of 0,5 cm3, the average titers of antibodies to the avian influenza virus subtype H5 on the 28th day after administration of the drug were 1:224. Studies have established the immunogenic capabilities of the vaccine from the recombinant strain. The results of the experiments showed the advantage of using a recombinant strain adapted to embryos instead of the field avian influenza virus subtype H5.

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