EPIDEMIOLOGY OF WEST NILE FEVER, PATHWAYS OF TRANSMISSION AND CAUSATIVE AGENT OF DISEASES

West Nile fever is a natural focal vector–borne viral infection characterized by fever intoxication syndrome and frequent damage to the central nervous system. The disease was so named because the main manifestation was "feverishness" and it was first discovered in the West Nile district. This article describes the epizootological and epidemiological aspects of West Nile Fever in Kazakhstan and across Europe. It is considered one of the arbovirus infections, which belongs to the genus Flavivirus of the family Flaviviridae. The carriers of the West Nile Fever pathogen are mosquitoes of the genus Culex and some bird species like crows. Mosquitoes bite and infect healthy birds, animals and humans. People can get infected from animals. Complications of this disease can lead to meningitis in humans, muscle paralysis, and even death in animals and birds.
Currently, licensed vaccines against HPV disease do not exist for humans, there are effective vaccines for horses. In order to prevent infection during outdoor recreation around lakes, rivers and other places, it is necessary to use mosquito repellent creams or wear protective clothing.

1. Petersen L.R., Brault A.C., Nasci R.S. West Nile virus: review of the literature.// JAMA, 2013, vol. 310, no. 3, pp. 308–315. DOI: 10.1001/jama.2013.8042

2. https://www.who.int/ru

3. Smithburn K. C., Hughes T. P., Burke A. W., Paul J. H. // Am J Trop Med Hyg. - 1940. - P. 471-492.

4. Chumakov M. P., Belyaeva N. K., Butenko A.M., Martianova L. I. West Nile virus in the USSR // Epidemiology of viral infections. - M., 1968. - Vol. 12. - pp. 365-373.

5. Butenko A.M., Chumakov M. P., Bashkirtsev V. N., etc. New data on the study of West Nile infection in the USSR (in the Astrakhan region) // Materials of the 15th Scientific. Sessions of the IPVE of the USSR Academy of Medical Sciences. - M., 1968. - pp. 175-176.

6. Murgue B., Murri S., Triki H., Deubel V., Zeller H.G // West Nile in the Mediterranean basin: 1950-2000 Ann. N Y Acad. Sci. - 2001. - Vol. 951. - P. 117-126. DOI: 10.1111/j.1749-6632.2001.tb02690.x.

7. Chancey C., Grinev A., Volkova E., Rios M. // The global ecology and epidemiology of West Nile virus / Biomed. Res. Int. - 2015. - Vol. 2015. - P. 376230. DOI: 10.1155/2015/376230.

8. Mencattelli G., Ndione M.H.D., Rosà R., Marini G., Diagne C.T., Diagne M.M., Fall G., Faye O Savini G., Rizzoli A. // Epidemiology of West Nile virus in Africa: An underestimated threat [et al.] PLoS Negl. Trop. Dis. - 2022. - Vol. 16, № 1. - P. e0010075. DOI: 10.1371/journal.pntd.0010075.

9. Habarugira G., Suen W.W., Hobson-Peters J., Hall R.A., Bielefeldt-Ohmann H. West Nile virus: an update on pathobiology, epidemiology, diagnostics, control and "one health" implications / // Pathogens. - 2020. - Vol. 9, № 7. - P. 589. DOI: 10.3390/pathogens9070589

10. Sambri, V.; Capobianchi, M.; Charrel, R.; Fyodorova, M.; Gaibani, P.; Gould, E.; Niedrig, M.; Papa, A.; Pierro, A.; Rossini, G. West Nile Virus in Europe: Emergence, epidemiology, diagnosis, treatment, prevention. Clin. Microbiol. Infec. 2013, doi:10.1111/1469-0691.12211

11. Butenko A.M., Kovtunov A.I., Dzharkenov A.F., Zlobina L.V., Grisnanova A.P., Azaryan A.R., Larichev V.F., Shishkino E.O., Lvov D.K. Epidemioloqical characteristics of West Nile fever in the Astrakhan reqion // Questions of viroloqy.-2001.-vol.46, No.4.-pp. 34-35.

12. Khan L.L., Popovich F., Alexander J.P., Laurentia V., Tengelsen L.A., Cernescu S. Risk factors for infection with West Nile virus and meningoencephalitis, Romania, 1996. J Infect Dis. 1999; 179:230-3. DOI external link PubMed external link Google Scholar external link.

13. Braunstein J.S., Rosen H., Purdy D., Miller J.R., Merlino M., Mostashari F.Spatial analysis of West Nile virus: a rapid assessment of the risk of vector-borne zoonosis. Vector zoonotic dis. 2002; 2: 157-64. DOI external link PubMed external link Google Scholar external link.

14. Maikanov N.S., Ayazbaev T.Z. Epidemiological significance and species composition (Culicidae) Western Kazakhstan // Mat. npk S.M.uch "Actual problems of epidemiology, microbiology, natural foci of human diseases". – Omsk: 2016. - №4(22). - Pp. 45-48

15. Medlock, J.M., Snow, K.R. and Leach, S. Possible ecology and epidemiology of medically important mosquito-borne arboviruses on Great Britain. // Epidemiology Infection, 2007, 135: 466- 482

16. Hayes E.B., O'Leary D.R. West Nile virus infection: a pediatric perspective // Pediatrics. 2004; 113:1375-81. DOI external link PubMed external link Google Scholar external link.

17. Anis E., Grotto I., Mendelson E., Bin H., Orshan L., Gandacu D., Warshavsky B., Shinar E., Slater P.E., Lev B. West Nile fever in Israel: the reemergence of an endemic disease // J Infect, 2014, vol.68, no.2, pp. 170-5. doi: 10.1016/j.jinf.2013.10.009

18. Kumar D., Prasad G.V., Saltzman J., Levy G.A., Humara A. Community-acquired infection with West Nile virus in recipients of parenchymal organ transplants // Transplantation. 2004; 77: 399 – 402.DOI external link PubMed external link Google Scholar external link.

19. Prilipov A.G. Genetic characterization of West Nile virus strains (Published doctoral dissertation). Federal State Budgetary Institution “Federal Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamalei” of the Ministry of Health of the Russian Federation, 2015, Moscow, Russia.

20. Guidelines 4.2.30009-12. Methods of control. Biological microbial factors. The procedure for organizing and conducting laboratory diagnostics of West Nile fever for laboratories at the territorial, regional and federal levels (Date of introduction 2012-03-29).

21. Mukhopadhyay, With consideration for; Kim, Bong-suk; Chapman, Paul R.; Grossman, Michael G.; Kuhn, Richard J. (October 10, 2003). "The structure of the West Nile virus" //Science. 302 (5643): 248. Do: 10.1126/science.1089316 .ISSN 0036-8075. PMID 14551429. S2CID 23555900.

22. Green M., Weinberger M., Ben-Ezer J., Bin H., Mendelson E., Gandacu D. еt al. Longterm death rates, West Nile virus epidemic // Israel, 2000. Emerg // Infect. Dis. 2005; 11:1754–7.

23. Kanai, Ryuta; Kar, Kalipada; Anthony, Karen; Gould, L. Hanna; Ledize, Michel; Fikrig, Erol; Marasco, Wayne A.; Koski, Raymond A.; Modis, Yorgo (November 1, 2006) The crystal structure of the glycoprotein envelope of the West Nile virus reveals the surface epitopes of the virus //Journal of Virology. 80 (22): 11000-11008. doi: 10.1128/jvi.01735-06. ISSN 0022-538X. PMC1642136. PMID 16943291.

24. Colpitts, T. M., Conway, M. J., Montgomery, R. R., & Fikrig, E. (2012). West nile virus Biology, transmission, and human infection Clinical Microbiology Reviews // 25(4), 635–648. // https://doi.org/10.1128/ CMR.00045-12

25. Rizzo, C.; Salcuni, P.; Nicoletti, L.; Ciufolini, M.; Russo, F.; Masala, R.; Frongia, O.; Finarelli, A.; Gramegna, M.; Gallo, L. Epidemiological surveillance of West Nile neuroinvasive diseases in Italy, 2008 to 2011. Euro Surveill. 2012, 17, 20.

26. Urbanowski, Matt D.; Hobman, Tom S. (January 15, 2013). West Nile virus capsid protein blocks apoptosis by phosphatidylinositol-3-kinase-dependent mechanism // Journal of Virology. 87 (2): 872-881. doi: 10.1128/jvi.02030-12 . ISSN 0022-538X. PMK 3554064. PMID 23115297.

27. Mertens, Laurent; Karnek, Xavier; Leon, Manuel Pereira; Ramdasi, Rasika; GibelBenassin, Florence; Lew, Erin; Lemke, Greg; Schwartz, Olivier; Amara, Ali (2012). The phosphatidylserine receptor families TIM and TAM mediate the penetration of the dengue virus // The host cell and the microbe. 12 (4): 544-557. 10.1016/j.chem.2012.08.009. PMC 3572209. PMID 23084921.

28. Carro, Ana S.; Damonte, Elsa B. (2013). "The need for cholesterol in the viral envelope for infection with the dengue virus." // Viral research. 174 (1–2): 78–87. doi: 10.1016/j.virusres.2013.03.005 . hdl: 11336/85262 . PMID 23517753.

29. Martin-Acebes, Miguel A.; Merino-Ramos, Teresa; Blases, Ana-Belen; Casas, Josephine; Escribano-Romero, Estela; Sobrino, Francisco; Saiz, Juan Carlos (October 15, 2014). The composition of the lipid chain of West Nile virus reveals the role of sphingolipid metabolism in the biogenesis of flaviviruses" // Journal of Virology. 88 (20): 12041-12054. doi: 10.1128/jvi.02061-14 . ISSN 0022-538X. PMC 4178726. PMID 25122799.

30. Medigeshi, Guruprasad R.; Hirsch, Alec J.; Streblow, Daniel N.; Nikolic-Zugic, Janko; Nelson, Jay A. (June 1, 2008). The penetration of West Nile virus requires membrane microdomains rich in cholesterol and does not depend on integrin avß3 // Journal of Virology. 82 (11): 5212–5219. dpi: 10.1128/jvi.00008-08 . ISSN 0022-538X. PMK 2395215. PMID 18385233.

31. Vilibic-Cavlek T., Savic V., Sabadi D., Peric L., Barbic L., Klobucar A., Miklausic B., Tabain I., Santini M., Vucelja M., Dvorski E., Butigan T., Kolaric-Sviben G., Potocnik-Hunjadi T., Balenovic M., Bogdanic M., Andric Z., Stevanovic V., Capak K., Balicevic M., Listes E., Savini G. Prevalence and molecular epidemiology of West Nile and Usutu virus infections in Croatia in the ‘One health’context, 2018. // Transbound Emerg. Dis. 2019; 66(5):1946–57. DOI: 10.1111/tbed.13225.

32. Haussig J.M., Young J.J., Gossner C.M., Mezei E., Bella A., Sirbu A., Pervanidou D., Drakulovic M.B., Sudre B. Early start of the West Nile fever transmission season 2018 in Europe // Euro Surveil. 2018; 23(32):1800428. DOI: 10.2807/1560-7917. ES.2018.23.32.1800428.

33. Shaimerdenova B.E., Kulemin M.V., Atovullayeva L.M., Nurmakhanov N.I. // Results of studies on tick-borne encephalitis and West Nile fever on the territory of Turkestan oblast. Proceedings of scientific-practical conference “Modern technologies of diagnosis, treatment, prevention of infectious and parasitic diseases”, Bukhara, Uzbekistan.

34. Majkanov N.S., Ajazbaev T.Z. Epidemic significance and mosquito species composition (Culicidae) in Western Kazakhstan. National Priorities of Russia. 2016, vol.4 (22). Retrieved from https://cyberleninka.ru/article/n/epidemicheskoe-znachenie-i-vidovoy-sostav-komarov-culicidaeZapadnogo-Kazahstana.

35. Leblond, A.; Sandoz, A.; Lefebvre, G.; Zeller, H.; Bicout, D. Remote sensing based identification of environmental risk factors associated with West Nile Disease in horses in Camargue, France // Prev. Vet. Med. 2007, 79, 20–31.

36. https://www.fao.org

37. https://www.who.int/zh/news-room/fact-sheets/detail/west-nile-virus

38. https://www.gov.uk/guidance/west-nile-virus#west-nile-virus-infection

39. https://www.who.int/ru

40. Medlock, J.M., Snow, K.R. and Leach, S. () Possible ecology and epidemiology of medically important mosquito-borne arboviruses on Great Britain // Epidemiology and infection, 2007, 135: 466- 482.

41. Hannoun C, Panthier R, Mouchet J, Eouzan JP. Isolement en France du virus West Nile à partir de malades et du vecteur Culex molestus Ficalbi. Compte Rendu de Académie des Sciences 1964;D259:4170-2.

42. Filipe AR. Isolation in Portugal of West Nile virus from Anopheles maculipennis mosquitoes. // Acta Virol 1972; 16:361.

43. Abdelhaq AT. West Nile fever in horses in Morocco. Bulletin de Office International des Épizooties 1996; 108: 867-9.

44. Hubálek Z, Halouzka J, Juricová Z. West Nile fever in Czechland // Emerg Infect Dis 1999; 5: 594-5