DETERMINATION OF THE OPTIMUM IMMUNIZING DOSE OF INACTIVATED VACCINE AGAINST CAMEL POX

The paper presents the results of determining the optimal immunising dose of inactivated vaccine against camelpox from the strain "KM - 40", obtained from the Republican Depository of especially dangerous pathogens of the Research Institute of Biological Safety Problems. The results of studies showed that intramuscular administration of inactivated vaccine against camelpox on camel rats formed antibodies to camelpox virus, the titre of which depended on the dose of the preparation. At 14 days after vaccination no antibodies were detected in the blood serum of camels immunised with the vaccine in the volumes of 2.0 and 3.0 ml, whereas in animals immunised in the volume of 5.0 ml the antibody titre was 1:2 and 1:4 in the neutralisation reaction and diffusion precipitation reaction, respectively. For use in the field, we recommend the use of 5.0 ml vaccine. If all the requirements specified in the regulations on vaccine production and control are met, this dose of the vaccine preparation ensures the formation of intense immunity against camelpox.

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