biobБиобезопасность и БиотехнологияBiosafety and Biotechnology2707-72412957-5702Научно-исследовательский институт проблем биологической безопасности10.58318/2957-5702-2022-11-13-22biob-30Research ArticleБИОЛОГИЧЕСКАЯ БЕЗОПАСНОСТЬ И БИОЗАЩИТАBIOLOGICAL SAFETY AND BIOSECURITYСРАВНЕНИЕ РЕЗУЛЬТАТОВ КУЛЬТИВИРОВАНИЕ КЛЕТОК И ВИРУСОВ НА НОВОМ МИКРОНОСИТЕЛЕ SEPLIFE® LX-MC-DEX1 С СУЩЕСТВУЮЩИМИ МИКРОНОСИТЕЛЯМИCOMPARISON OF THE RESULTS OF CULTURING CELLS AND VIRUSES ON THE NEW SEPLIFE® LX-MC-DEX1 MICROCARRIER WITH EXISTING MICROCARRIERSТұрыскелдіШ. С.TuryskeldiSh. S.smankizi@mail.ruСаметоваЖ. Ж.SametovaZh. Zh.ҮсембайА. Қ.UsembayA. K.БулатовЕ. А.BulatovYe. A.Научно-исследовательский институт проблем биологической безопасностиКазахстанScientific Research Institute of Biological Safety ProblemsKazakhstan2022250120230111322Copyright © Тұрыскелді Ш.С., Саметова Ж.Ж., Үсембай А.Қ., Булатов Е.А., 20232023Тұрыскелді Ш.С., Саметова Ж.Ж., Үсембай А.Қ., Булатов Е.А.Turyskeldi S.S., Sametova Z.Z., Usembay A.K., Bulatov Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.biosafety.kz/jour/article/view/30

микроносители представляют собой мелкие твердые частицы размером 90–350 мкм, на поверхности которых в виде монослоя растут клетки. Две основные свойства микроносителей являются клеточная адгезия и высокая продукция клеток. По результатам сравнительного исследования, проведенного по различным параметрам, было определено, что каждый микроноситель имеет свои преимущества и недостатки. В нашем исследовании сравнивались свойства микроносителей SEPLIFE® LX-MC-dex1 и Cytodex 3. По результатам исследований установлено, что LXMC-DEX1, содержащий искусственное вещество, по всем свойствам и удобству применения не уступает широко применяемому в производстве микроносителю Cytodex 3. Основным преимуществом микроносителя SEPLIFE® LX-MC-dex1 является его ценовая эффективность, то есть он в 5 раз дешевле, чем Cytodex 3. В связи с этим микроноситель SEPLIFE® LX-MC-dex1 был признан экономически выгодным

microcarriers are small solid particles 90–350 µm in size, on the surface of which cells grow in the form of a monolayer. The two main properties of microcarriers are cell adhesion and high cell production. According to the results of a comparative study conducted on various parameters, it was determined that each microcarrier has its own advantages and disadvantages. In our study, the properties of SEPLIFE® LX-MC-dex1 and Cytodex 3 microcarriers were compared. According to the results of the studies, it was found that SEPLIFE® LX-MC-dex1, containing an artificial substance, is not inferior to Cytodex 3 microcarrier widely used in production in all properties and ease of use. The main advantage of the SEPLIFE® LX-MC-dex1 microcarrier is its cost effectiveness, i.e. it is 5 times cheaper than Cytodex 3. In this regard, the SEPLIFE® LX-MC-dex1 microcarrier was found to be cost-effective.

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The authors declare that there are no conflicts of interest present.