biobБиобезопасность и БиотехнологияBiosafety and Biotechnology2707-72412957-5702Научно-исследовательский институт проблем биологической безопасности10.58318/2957-5702-2025-24-34-43biob-221Research ArticleСТАТЬИArticlesГЕМАТОЛОГИЧЕСКИЕ ПОКАЗАТЕЛИ ПОСЛЕ ИНФИЦИРОВАНИЯ КОЗ ПЛАЗМИДОЙ PVAPA ШТАММА RHODOCOCCUS EQUIHEMATOLOGICAL PARAMETERS AFTER INFECTION OF GOATS WITH THE RHODOCOCCUS EQUI PVAPA PLASMIDhttps://orcid.org/0000-0001-7140-2961ИлгекбаеваГ. Д.IlgekbayevaG. D.

Ильгекбаева Гульназ Дуйсековна - доктор ветеринарных наук, профессор кафедры «Биологическая безопасность».

Алматы

Almaty

gulnaz66@mail.ruhttps://orcid.org/0000-0002-8280-367XОтарбаевБ. К.OtarbayevB. K.

Almaty

bauken_68@mail.ruhttps://orcid.org/0009-0000-6710-2368ЗанилабдинМ. З.ZanilabdinM. Z.

Занилабдин Макпал Занилабдинкызы - магистр ветеринарной санитарии.

Алматы

Almaty

zhabykpaev1994@gmail.comhttps://orcid.org/0000-0003-3852-2472КурманС.KurmanS.

Курман Серикжан - магистр сельскохозяйственных наук.

Алматы

Almaty

Seke7021@gmail.comhttps://orcid.org/0009-0000-8651-6523ЖолдасУ.ZholdasU.

Жолдас Улан - магистр ветеринарии.

Алматы

Almaty

ulanzholdass@mail.comhttps://orcid.org/0009-0003-4995-0592КадеевА. М.KadeyevA. M.

Кадеев Айбек Мухтарулы – магистрант.

Алматы

Almaty

aibek2448@gmail.comhttps://orcid.org/0009-0004-2263-0940ВалиеваБ. А.ValievaB. A.

Валиева Баян Азатовна - лаборант кафедры «Биологическая безопасность».

Алматы

Almaty

valievabayan1973@gmail.comКазахский национальный аграрный исследовательский университетКазахстанKazakh National Agrarian Research UniversityKazakhstan2025100420260243443Copyright © Илгекбаева Г.Д., Отарбаев Б.К., Занилабдин М.З., Курман С., Жолдас У., Кадеев А.М., Валиева Б.А., 20262026Илгекбаева Г.Д., Отарбаев Б.К., Занилабдин М.З., Курман С., Жолдас У., Кадеев А.М., Валиева Б.А.Ilgekbayeva G.D., Otarbayev B.K., Zanilabdin M.Z., Kurman S., Zholdas U., Kadeyev A.M., Valieva B.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.biosafety.kz/jour/article/view/221

В исследовании оценивали временную динамику гематологических показателей у коз зааненской породы в возрасте 2–3 месяцев после введения вирулентных pVapAположительных штаммов Rhodococcus equi. В период 0–65 суток в сравнении с контрольной группой анализировали показатели гемоглобина (Hb), эритроцитов (RBC), лейкоцитов (WBC), гематокрита (HCT), а также MCV, MCH, MCHC и RDW. В целом в основные временные точки между группами не было выявлено стойких статистически значимых различий. Только по показателю Hb в группе VapA-108 на 65-е сутки отмечено снижение по сравнению с контролем (p=0,033), однако малое число животных в каждой группе (n=3) требует осторожной интерпретации этого результата. Широкие 95% доверительные интервалы и высокие коэффициенты вариации свидетельствовали о выраженной индивидуальной вариабельности. Полученные данные показывают, что в модели на козах pVapA-положительные штаммы R. equi вызывали скорее слабый и вариабельный ответ, чем выраженные и стойкие системные гематологические нарушения.

This study evaluated the temporal dynamics of hematological parameters in 2–3-monthold Saanen goats after inoculation with virulent pVapA-positive Rhodococcus equi strains. Hemoglobin (Hb), red blood cells (RBC), white blood cells (WBC), hematocrit (HCT), MCV, MCH, MCHC, and RDW were analyzed over a 0–65-day period in comparison with the control group. Overall, no persistent statistically significant differences were detected between the groups at the main time points. A decrease in Hb was observed only in the VapA-108 group on day 65 compared with the control (p=0.033); however, the small number of animals in each group (n=3) requires cautious interpretation of this result. The wide 95% confidence intervals and high coefficients of variation indicated marked individual variability. The obtained data suggest that, in the goat model, pVapA-positive R. equi strains induced a weak and variable response rather than pronounced and persistent systemic hematological alterations.

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The authors declare that there are no conflicts of interest present.